Societies will not make a significant dent to any of their grand challenges until they engage the private sector. Companies can achieve scale, permanence and efficiency that are elusive to government and civil society organizations (Austin & Chu, 2006). In Latin America, business involvement with challenges like poverty, corruption, illiteracy, racism, hunger and inequality has been minimal. But this is changing. This study explores how institutional entrepreneurs have integrated social and economic dimensions within their ventures in contexts where previously these dimensions have been separated. The contrasts between the distinct interventions of entrepreneurs within four industries (i.e., construction, restaurants, oil and micro-finance), illustrate some of the effects on stakeholders, industry and beyond. The study enhances our understanding of how the creation of new organizational practices in established fields bring about change. These changes are characterized by a greater degree of isomorphism within private sector companies and, to a lesser degree, within social enterprises and civil society organizations.